Greetings Wisconsin Outdoorsman Hunters et al, does not seem to appear that CWD is discussed here very much ??? Wisconsin Wildlife Diseases Bovine tuberculosis, Chronic wasting disease, etc. https://www.wisconsinoutdoorsman.com/forum/forumdisplay.php?f=14 SO, I thought I would jump off on a limb here, and attempt to pass along some information here on Chronic Wasting Disease and other TSE prion type disease, games farm, the threat there from, and human and animal ramifications there from. before you shoot the messenger, i am not trolling here, i am a meat eater, i am pro-hunter, i simply made a promise to my mom DOD 12/14/97 hvCJD ‘confirmed’. simple as that. now, i am not going to take up much of your time, i am going to post some links, and move on. if you have any questions, if i have not been shot by then, please feel free to ask them. i am vested in nothing but the truth, i have wasted 14 years trying to warn folks about a disease that nobody wants to talk about, nobody wants to hear about, that everybody wants to ignore. Wisconsin cannot stop it’s battle with CWD. I lost my mother to the hvCJD ‘confirmed’, here in Texas. since then, I have followed the TSE prion mad cow saga daily. what I have discovered is very disturbing, and most of which the common layperson or hunter just does not know about. oh well, here goes, and your not going to like it. ... now, bash me if you must. ... :bash: :hide: Don’t Forget CWD Sunday, January 22nd, 2012 | Posted by Dr. Dave Samuel Nebraska just announced the finding of Chronic Wasting Disease in several counties in the center of the state. This shows the continued spread from western Nebraska. So what you say, “It’s obvious that CWD can’t spread to humans and it sure doesn’t seem to be hurting our deer herds.” Maybe. Maybe on both counts. The release of information showing the spread of CWD in Nebraska (where I hunt every fall in the eastern part of the state) caused me to check out the website, http://transmissiblespongiformencephalopathy.blogspot.com/ . That blog lists a lot of other website with tons of information on CWD. CWD is not spread by bacteria but rather by prions that invade and destroy the brain. One very similar disease of humans is Creutzfeldt-Jacob Disease. This blog presents a lot of information on that disease relative to whether humans can get CWD from diseased deer or elk. Bottom line is that we don’t know a lot about prions. We do know that prions survive in soil for years. We know that deer can be placed in an area where CWD lived and after being removed for over a year, deer placed there again get CWD. We don’t know how long prions stay viable in the soil. My guess is . . . many, many years. Maybe decades. We know that deer have prions in nervous tissue but also in lymph tissue and even muscles. We know that prions are spread via saliva and urine. (In fact that is why many states are concerned about baiting for deer.) We don’t think prions can be spread via eating deer meat but we aren’t positive. Scary because another prion disease ‘mad cow disease’ can be spread from cows to humans leading to death. I don’t want to play the ‘what if’ game, but ‘what if’ one hunter got CWD from eating deer meat and that hunter died? Let’s not go there. The ramifications are beyond comprehension. Another aspect of this problem is found on the above website as well as http://chronic-wasting-disease.blogspot.com/ . I invite you to go to this website and after you peruse it you will see the relationship of CWD and deer farms. They discuss the Almond deer farm in Wisconsin. A buck shot there in 2002 had CWD and this led to all deer there being killed in 2006. Sixty of the 76 deer killed were CWD positive. In order to keep control of this situation and make sure the fence separating the contaminated farm from wild deer remained intact, the DNR bought the farm in 2011. Remember, this farm probably has CWD prions in the soil, so the potential for spread to wild deer is real. However, 1200 deer outside the farm have been tested and no CWD was found. The DNR wants to make sure the fences stay intact, so they bought it and will do research on CWD there. Seems like a good idea. A total decontamination of the farm was conducted, but there is no way to know whether prions are still in the soil. They probably are. All timber along the fence is being cut to protect the fence. A second fence 12 feet from the first is being constructed. Apparently the Wisconsin DNR is very concerned about the spread of CWD. If baiting for deer has been shown to exacerbate the spread of CWD then why do we find baiting being legalized in more and more states? The reason is simple. Hunters want baiting and they apply political pressure to keep baiting if they have it or to get baiting if they do not have it. The DNR in my home state of West Virginia would love to stop baiting for deer to prevent, or slow the spread of CWD from the eastern panhandle of the state, but the hunters won’t let that happen. A political hot potato. Again, check out the above two web sites then tell me that CWD is not a potential problem for hunters and deer. This ain’t your average disease. So far, humans eating venison are OK and so far deer herds are OK too. But packing large numbers of deer in small areas is an experiment and only time will tell if ‘it’s not nice to fool with Mother Nature.’ http://bowhunting.net/2012/01/dont-forget-cwd/ THIS NEW WARNING JUST CAME OUT... Thursday, January 26, 2012 The Risk of Prion Zoonoses Science 27 January 2012: Vol. 335 no. 6067 pp. 411-413 DOI: 10.1126/science.1218167 http://transmissiblespongiformencephalopathy.blogspot.com/2012/01/risk-of-prion-zoonoses.html Thursday, January 26, 2012 Facilitated Cross-Species Transmission of Prions in Extraneural Tissue Science 27 January 2012: Vol. 335 no. 6067 pp. 472-475 DOI: 10.1126/science.1215659 http://www.sciencemag.org/content/335/6067/472.full more here ; “which may prompt a reevaluation of the effectiveness of species barriers” Thursday, January 26, 2012 Facilitated Cross-Species Transmission of Prions in Extraneural Tissue Science 27 January 2012: Vol. 335 no. 6067 pp. 472-475 DOI: 10.1126/science.1215659 http://transmissiblespongiformencep...1/facilitated-cross-species-transmission.html Sunday, January 29, 2012 Pharmaceuticals and TSE prion disease Prion Disease Risks in the 21st Century 2011 PDA European Virus-TSE Safety Dr. Detwiler Dr. Detwiler published Prion Disease Risks in the 21st Century 2011 PDA European Virus-TSE Safety Forum\Presentations TSE\ Page 33 and 34 of 44 ; http://www.pda.org/ snip... Dr. Detwiler section on CWD in cervids state ; Chronic Wasting Disease Spreading throughout the US and Western Canada Elk, deer and moose Imported and domestic cases in South Korea (Canadian origin) Widespread tissues distribution (LRS,CNS, saliva, blood, urine) ==================================== Dr. Detwiler states here that ; Conclusions: Threats to Biopharmaceuticals Sourcing of raw materials from countries with poorly defined risks Lack of compliance (SRM controls; Feed bans) Premature relaxation of regulations Emerging TSEs – Atypical BSE; Atypical scrapie Chronic Wasting Disease – new strains, unchecked spread, new species? TSEs spreading to other species – e.g.. swine Infectivity in absence of PrPsc ==================end...tss=================== snip...more here ; http://transmissiblespongiformencep...2/01/prion-disease-risks-in-21st-century.html CHRONIC WASTING DISEASE CWD WISCONSIN Almond Deer (Buckhorn Flats) Farm Update DECEMBER 2011 Form 1100-001 (R 2/11) NATURAL RESOURCES BOARD AGENDA ITEM SUBJECT: Inf01mation Item: Almond Deer Fatm Update FOR: DECEIVIBER 2011 BOARD MEETING SNIP... These laboratory results show that 60 of the 76 animals tested positive for chronic wasting disease. The 76 deer constituted the breeding herd on Hall’s farm. He also operated a hunting preserve on the property until 2005. Four deer, two does and two fawns, the only deer remaining in the former preserve, were killed and tested as well. CWD was not detected in those animals. The total number of deer to test positive from this farm from the initial discovery to final depopulation is 82. The CWD infection rate was nearly 80%, the highest ever in a North American captive herd. SNIP... Despite the five year premise plan and site decontamination, The WI DNR has concerns over the bioavailability of infectious prions at this site to wild white-tail deer should these fences be removed. Current research indicates that prions can persist in soil for a minimum of 3 years. However, Georgsson et al. (2006) concluded that prions that produced scrapie disease in sheep remained bioavailable and infectious for at least 16 years in natural Icelandic environments, most likely in contaminated soil. Additionally, the authors reported that from 1978-2004, scrapie recurred on 33 sheep farms, of which 9 recurrences occurred 14-21 years after initial culling and subsequent restocking efforts; these findings further emphasize the effect of environmental contamination on sustaining TSE infectivity and that long-term persistence of prions in soils may be substantially greater than previously thought. Evidence of environmental transmission also was documented in a Colorado research facility where mule deer became infected with CWD in two of three paddocks where infected deer carcasses had decomposed on site 1.8 years earlier, and in one of three paddocks where infected deer had last resided 2.2 years earlier (Miller et al. 2004). SNIP... http://dnr.wi.gov/org/nrboard/2011/december/12-11-2b2.pdf FULL TEXT AND MORE HERE ; http://chronic-wasting-disease.blogspot.com/2011/12/chronic-wasting-disease-cwd-wisconsin.html with 9 infected game farms documented to date in Wisconsin, with one of them having the highest infection rate ever in the world i.e. 80%, I think it’s time for all of these game farms to be shut down. just my opinion. ...TSS Comment from Terry Singeltary Document ID: APHIS-2011-0032-0002Document Type: Public Submission This is comment on Notice: Agency Information Collection Activities; Proposals, Submissions, and Approvals: Chronic Wasting Disease Herd Certification Program Docket ID: APHIS-2011-0032RIN: Topics: No Topics associated with this document View Document: Show Details Document Subtype: Public Comment Status: Posted Received Date: January 24 2012, at 12:00 AM Eastern Standard Time Date Posted: January 25 2012, at 12:00 AM Eastern Standard Time Comment Start Date: January 24 2012, at 12:00 AM Eastern Standard Time Comment Due Date: March 26 2012, at 11:59 PM Eastern Daylight Time Tracking Number: xxxxxxx First Name: Terry Middle Name: S. Last Name: Singeltary City: Bacliff Country: United States State or Province: TX Organization Name: LAYPERSON Submitter's Representative: CJD TSE PRION VICTIMS Name: Terry S. Singeltary Address: Bacliff, TX, Submitter's Representative: CJD TSE PRION VICTIMS Organization: LAYPERSON -------------------------------------------------------------------------------- General Comment Agency Information Collection Activities; Proposals, Submissions, and Approvals: Chronic Wasting Disease Herd Certification Program (Document ID APHIS-2011-0032-0001) I believe that any voluntary program for CWD free herd certification from game farms will be futile, as was the partial and voluntary mad cow feed ban of August 4, 1997. That failed terribly, with some 10,000,000 of banned blood laced MBM being fed out in 2007, a decade post August 4, 1997 partial and voluntary ban. Game farms are a petri dish for CWD TSE Prion disease, with Wisconsin having documented 9 CWD infected game farms, with one having the highest CWD infection rate in the world, 80% CWD infection rate. I believe that all game farms should be SHUT DOWN PERMANENTLY. CWD TSE prion disease survives ashing to 600 degrees celsius, that’s around 1112 degrees farenheit. you cannot cook the CWD TSE prion disease out of meat. you can take the ash and mix it with saline and inject that ash into a mouse, and the mouse will go down with TSE. Prion Infected Meat-and-Bone Meal Is Still Infectious after Biodiesel Production as well. the TSE prion agent also survives Simulated Wastewater Treatment Processes. IN fact, you should also know that the CWD TSE Prion agent will survive in the environment for years, if not decades. you can bury it and it will not go away. CWD TSE agent is capable of infected your water table i.e. Detection of protease-resistant cervid prion protein in water from a CWD-endemic area. it’s not your ordinary pathogen you can just cook it out and be done with. that’s what’s so worrisome about Iatrogenic mode of transmission, a simple autoclave will not kill this TSE prion agent. Tuesday, December 20, 2011 CHRONIC WASTING DISEASE CWD WISCONSIN Almond Deer (Buckhorn Flats) Farm Update DECEMBER 2011 http://dnr.wi.gov/org/nrboard/2011/december/12-11-2b2.pdf http://chronic-wasting-disease.blogspot.com/ full submission here ; http://www.regulations.gov/#!documentDetail;D=APHIS-2011-0032-0002 Friday, February 25, 2011 Soil clay content underlies prion infection odds http://chronic-wasting-disease.blogspot.com/2011/02/soil-clay-content-underlies-prion.html Monday, August 8, 2011 Susceptibility of Domestic Cats to CWD Infection Oral.29: Susceptibility of Domestic Cats to CWD Infection see also ; Enzymatic Digestion of Chronic Wasting Disease Prions Bound to Soil CWD TSE prion disease survives ashing to 600 degrees celsius, that’s around 1112 degrees farenheit. Prion Infected Meat-and-Bone Meal Is Still Infectious after Biodiesel Production Detection of protease-resistant cervid prion protein in water from a CWD-endemic area see this and more here ; http://felinespongiformencephalopat...8/susceptibility-of-domestic-cats-to-cwd.html *** Spraker suggested an interesting explanation for the occurrence of CWD. The deer pens at the Foot Hills Campus were built some 30-40 years ago by a Dr. Bob Davis. At or abut that time, allegedly, some scrapie work was conducted at this site. When deer were introduced to the pens they occupied ground that had previously been occupied by sheep. (PLEASE NOTE SOME OF THESE OLD UK GOVERNMENT FILE URLS ARE SLOW TO OPEN, AND SOMETIMES YOU MAY HAVE TO CLICK ON MULTIPLE TIMES, PLEASE BE PATIENT, ANY PROBLEMS PLEASE WRITE ME PRIVATELY, AND I WILL TRY AND FIX OR SEND YOU OLD PDF FILE...TSS) http://collections.europarchive.org...www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf Wednesday, November 16, 2011 Wisconsin Creutzfeldt Jakob Disease, CWD, TSE, PRION REPORTING 2011 http://transmissiblespongiformencep.../wisconsin-creutzfeldt-jakob-disease-cwd.html Sunday, January 22, 2012 Chronic Wasting Disease CWD cervids interspecies transmission http://chronic-wasting-disease.blogspot.com/2012/01/chronic-wasting-disease-cwd-cervids.html CWD TSE PRION UPDATE JANUARY 26, 2012 Tuesday, January 24, 2012 CWD found in two free-ranging deer from Macon County Missouri http://chronic-wasting-disease.blogspot.com/2012/01/cwd-found-in-two-free-ranging-deer-from.html Wednesday, January 04, 2012 CWD NEBRASKA NGPC 26 DEER CARCASSES TESTED POSITIVE BUFFALO, CUSTER AND HOLT COUNTIES DURING NOVEMBER HUNT http://chronic-wasting-disease.blogspot.com/2012/01/cwd-nebraska-ngpc-26-deer-carcasses.html Saturday, December 31, 2011 Depopulation Plan Being Developed for Captive Deer Facility in Macon County after second CWD positive confirmation http://chronic-wasting-disease.blogspot.com/2011/12/depopulation-plan-being-developed-for.html Wednesday, December 21, 2011 CWD UTAH San Juan deer hunting unit http://chronic-wasting-disease.blogspot.com/2011/12/cwd-utah-san-juan-deer-hunting-unit.html Thursday, December 29, 2011 Aerosols An underestimated vehicle for transmission of prion diseases? PRION www.landesbioscience.com please see more on Aerosols and TSE prion disease here ;. ... http://transmissiblespongiformencep...1/12/aerosols-underestimated-vehicle-for.html Wednesday, January 18, 2012 BSE IN GOATS CAN BE MISTAKEN FOR SCRAPIE February 1, 2012 http://transmissiblespongiformencep...2012/01/bse-in-goats-can-be-mistaken-for.html I do this for one reason. educational purposes. please use this data as you wish. I do not advertise or make money from this, and I am vested in nothing but the truth. ... http://transmissiblespongiformencephalopathy.blogspot.com/ http://chronic-wasting-disease.blogspot.com/ http://scrapie-usa.blogspot.com/ http://nor-98.blogspot.com/ http://bse-atypical.blogspot.com/ http://bseusa.blogspot.com/ http://transmissible-mink-encephalopathy.blogspot.com/ :help: TSS
Subject: PRION 2017 CONFERENCE ABSTRACT First evidence of intracranial and peroral transmission of Chronic Wasting Disease (CWD) into Cynomolgus macaques: a work in progress First evidence of intracranial and peroral transmission of Chronic Wasting Disease (CWD) into Cynomolgus macaques: a work in progress Stefanie Czub1, Walter Schulz-Schaeffer2, Christiane Stahl-Hennig3, Michael Beekes4, Hermann Schaetzl5 and Dirk Motzkus6 1 University of Calgary Faculty of Veterinary Medicine/Canadian Food Inspection Agency; 2Universitatsklinikum des Saarlandes und Medizinische Fakultat der Universitat des Saarlandes; 3 Deutsches Primaten Zentrum/Goettingen; 4 Robert-Koch-Institut Berlin; 5 University of Calgary Faculty of Veterinary Medicine; 6 presently: Boehringer Ingelheim Veterinary Research Center; previously: Deutsches Primaten Zentrum/Goettingen This is a progress report of a project which started in 2009. 21 cynomolgus macaques were challenged with characterized CWD material from white-tailed deer (WTD) or elk by intracerebral (ic), oral, and skin exposure routes. Additional blood transfusion experiments are supposed to assess the CWD contamination risk of human blood product. Challenge materials originated from symptomatic cervids for ic, skin scarification and partially per oral routes (WTD brain). Challenge material for feeding of muscle derived from preclinical WTD and from preclinical macaques for blood transfusion experiments. We have confirmed that the CWD challenge material contained at least two different CWD agents (brain material) as well as CWD prions in muscle-associated nerves. Here we present first data on a group of animals either challenged ic with steel wires or per orally and sacrificed with incubation times ranging from 4.5 to 6.9 years at postmortem. Three animals displayed signs of mild clinical disease, including anxiety, apathy, ataxia and/or tremor. In four animals wasting was observed, two of those had confirmed diabetes. All animals have variable signs of prion neuropathology in spinal cords and brains and by supersensitive IHC, reaction was detected in spinal cord segments of all animals. Protein misfolding cyclic amplification (PMCA), real-time quaking-induced conversion (RT-QuiC) and PET-blot assays to further substantiate these findings are on the way, as well as bioassays in bank voles and transgenic mice. At present, a total of 10 animals are sacrificed and read-outs are ongoing. Preclinical incubation of the remaining macaques covers a range from 6.4 to 7.10 years. Based on the species barrier and an incubation time of > 5 years for BSE in macaques and about 10 years for scrapie in macaques, we expected an onset of clinical disease beyond 6 years post inoculation. PRION 2017 DECIPHERING NEURODEGENERATIVE DISORDERS TUESDAY, JUNE 13, 2017 PRION 2017 CONFERENCE ABSTRACT First evidence of intracranial and peroral transmission of Chronic Wasting Disease (CWD) into Cynomolgus macaques: a work in progress http://chronic-wasting-disease.blogspot.com/2017/06/prion-2017-conference-abstract-first.html FRIDAY, JUNE 16, 2017 P55 Susceptibility of human prion protein to in vitro conversion by chronic wasting disease prions http://chronic-wasting-disease.blogspot.com/2017/06/p55-susceptibility-of-human-prion.html SATURDAY, JUNE 10, 2017 Chronic Wasting Disease CWD TSE Prion to Humans, who makes that final call, when, or, has it already happened? http://chronic-wasting-disease.blogspot.com/2017/06/chronic-wasting-disease-cwd-tse-prion_10.html MONDAY, JUNE 12, 2017 Rethinking Major grain organizations opposition to CFIA's control zone approach to Chronic Wasting CWD TSE Prion Mad Deer Type Disease 2017? http://chronic-wasting-disease.blogspot.com/2017/06/rethinking-major-grain-organizations.html TUESDAY, JUNE 13, 2017 PRION 2017 CONFERENCE ABSTRACT Chronic Wasting Disease in European moose is associated with PrPSc features different from North American CWD http://chronic-wasting-disease.blogspot.com/2017/06/prion-2017-conference-abstract-chronic.html TUESDAY, JUNE 06, 2017 CHRONIC WASTING DISEASE CWD TSE PRION ZOONOSIS ZOONOTIC INSIDIOUS AND DIRE CONSEQUENCES AHEAD http://chronic-wasting-disease.blogspot.com/2017/06/chronic-wasting-disease-cwd-tse-prion.html TUESDAY, JUNE 13, 2017 Pennsylvania Chronic Wasting Disease CWD TSE PRION Senate Joint Hearing Tuesday, June 13, 2017 http://chronic-wasting-disease.blogspot.com/2017/06/pennsylvania-chronic-wasting-disease.html Terry S. Singeltary Sr.
